Environment and Breast Cancer: Science Review
About
Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 (UGT1A1) and risk of breast cancer
Adegoke, O. J., Shu, X. O., Gao, Y. T., Cai, Q., Breyer, J., Smith, J., Zheng, W. Breast Cancer Research and Treatment. 2004. 85:3, 239-45.
Topic area
Body size - Genetic variability
Body size - Genetic variability
Study design
Population based case-control study
Population based case-control study
Funding agency
USPHS, NCI
USPHS, NCI
Study Participants
Number of Cases
1193
1193
Menopausal Status
Post meopausal
The menopausal status of women included in this study is listed here.
Pre menopausalPost meopausal
Number of Controls
1310
1310
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
Parent study: Shanghai Breast Cancer Study. Rapid case ascertainment system with population-based Shanghai Tumor Registry, pathologist confirmed diagnosis. Controls were selected by Shanghai Resident Registry and frequency matched by age in 5-year intervals.
Exposures investigated
BMI/WHR, UGT1A1 allele frequencies, used PCR-RFLP
BMI/WHR, UGT1A1 allele frequencies, used PCR-RFLP
How exposure was measured
Biological Questionnaire, in-person
Biological Questionnaire, in-person
Breast cancer outcome investigated
Primary breast cancer
Primary breast cancer
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
No
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Adequately controlled
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
Yes
Description of major analysis
Logistic regression analysis of UGT1A1 genotype and breast cancer, including effect modification by BMI, WHR
Logistic regression analysis of UGT1A1 genotype and breast cancer, including effect modification by BMI, WHR
Strength of associations reported
UGT1A1*28 homozygous compared to UGT1A1*1 homozygous showed an adjusted OR=1.2 (CI: 0.6-2.2)
For women <40 years old with at least one UGT1A1*28 allele showed an OR=1.7 (CI: 1.0-2.8)
ER/PR status did not significantly alter OR’s across whole group, or stratified by age
Stratified analyses showed that women with WHR <0.80 and UGT1A1*28 allele showed an age adjusted OR=1.8 (CI: 1.0-3.5) compared to UGT1A1*1 homozygotes
Stratified analyses showed that women with BMI <23 and UGT1A1*28 showed an age adjusted OR=1.8 (CI: 1.0-3.5) compared to UGT1A1*1 homozygotes
UGT1A1*28 homozygous compared to UGT1A1*1 homozygous showed an adjusted OR=1.2 (CI: 0.6-2.2)
For women <40 years old with at least one UGT1A1*28 allele showed an OR=1.7 (CI: 1.0-2.8)
ER/PR status did not significantly alter OR’s across whole group, or stratified by age
Stratified analyses showed that women with WHR <0.80 and UGT1A1*28 allele showed an age adjusted OR=1.8 (CI: 1.0-3.5) compared to UGT1A1*1 homozygotes
Stratified analyses showed that women with BMI <23 and UGT1A1*28 showed an age adjusted OR=1.8 (CI: 1.0-3.5) compared to UGT1A1*1 homozygotes
Controls participation rate
Greater than 70%
Greater than 70%