Environment and Breast Cancer: Science Review

Evidence From Humans
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A population-based case-control study of the Arg399Gln polymorphism in DNA repair gene XRCC1 and risk of breast cancer
Shu, X. O., Cai, Q., Gao, Y. T., Wen, W., Jin, F., Zheng, W. Cancer Epidemiology, Biomarkers and Prevention. 2003. 12:12, 1462-7.
Topic area
Body size - Genetic variability
Study design
Population based case-control study
Funding agency
Study Participants
Menopausal Status
The menopausal status of women included in this study is listed here.
Pre menopausal
Post meopausal
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
Participants of the Shanghai Breast Cancer Study. Rapid case ascertainment system with population-based Shanghai Tumor Registry, pathologist confirmed diagnosis. Controls selected by Shanghai Resident Registry and frequency matched by age in 5-year intervals.
Exposures investigated
BMI, XRCC1 allele frequencies, used PCR-RFLP
How exposure was measured
Biological Questionnaire, in-person
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Adequately controlled
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
Description of major analysis
Logistic regression analysis of XRCC1 genotype and breast cancer, including effect modification by BMI
Strength of associations reported
In the full sample, heterozygotes (Arg/Gln) showed an adjusted OR=0.90 (0.76-1.08) and homozygotes (Gln/Gln) showed an adjusted OR of 1.20 (0.85-1.69) compared to wild type homozygotes (Arg/Arg)
For BMI <25, age-adjusted OR=0.92 (CI: 0.74-1.13) for Arg/Gln and 1.36 (CI: 0.93-2.01) in Gln/Gln
For BMI >=25, age-adjusted OR=0.88 (CI: 0.63-1.22) in Arg/Gln and 0.92 (CI: 0.44-1.91) in Gln/Gln
No statistically significant associations when BMI stratified analyses were computed for only postmenopausal women