Environment and Breast Cancer: Science Review

Evidence From Humans
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Cytochrome P450 1B1 gene polymorphisms and postmenopausal breast cancer risk
Rylander-Rudqvist, T., Wedren, S., Granath, F., Humphreys, K., Ahlberg, S., Weiderpass, E., Oscarson, M., Ingelman-Sundberg, M., Persson, I. Carcinogenesis. 2003. 24:9, 1533-9.
Topic area
Body size - Genetic variability
Study design
Population based case-control study
Funding agency
NIH, Swedish Cancer Society, Swedish Research Coun
Study Participants
Menopausal Status
The menopausal status of women included in this study is listed here.
Post menopausal
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
Incident cases of women age 50-74 living in Sweden classified in Swedish regional cancer registries. Controls were randomly selected in 5-year age strata from Swedish Population Register.
Exposure Investigated
Exposures investigated
BMI, CYP1B1 allele frequency, used PCR-RFLP
How exposure was measured
Biological Questionnaire, self-administered
Exposure assessment comment
Case and control selection included women with self-reported diabetes mellitus
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Adequately controlled
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
Description of major analysis
Logistic regression analysis of CYP1B1 genotype and breast cancer, including effect modification by BMI
Strength of associations reported
Crude association between CYP1B1 genotypes and BC risk showed no association
No association between any CYP1B1 genotypes and breast cancer risk by BMI subgroup; No data shown