Environment and Breast Cancer: Science Review

Evidence From Humans
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Serum sex hormones and breast cancer risk factors in postmenopausal women
Lamar, C. A., Dorgan, J. F., Longcope, C., Stanczyk, F. Z., Falk, R. T., Stephenson, H. E., Jr. Cancer Epidemiology, Biomarkers & Prevention. 2003. 12:4, 380-3.
Topic area
Body size
Study design
Other: Cross sectional analysis
Funding agency
Other: United States Government Intramural Funds
Study Participants
Menopausal Status
The menopausal status of women included in this study is listed here.
Post menopausal
Number of Controls
133 (women who participated and dontated blood)
Cohort participation rate
Retention/participation exceeded 70% for exposed a
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
In: served as controls for a prospective nested case control study; postmenopausal; donated blood to the Breast Cancer Serum Bank (Columbia, MO) between 1977 and 1987 Ex: took replacement estrogens at time of blood draw; previous cancer; diagnosed with benign breast disease within 2 years of blood collection
Comment about participation selection
Strengths: serum estrogen and serum androgen levels were analyzed by BMI and height; all models were adjusted for hormone analysis batch and date and time of day of blood collection; serial measurements of serum hormones in postmenopausal women suggest that a single measurement can reliably categorize women at least over the short term Limitations: clinical data was self-reported or obtained through medical records; cross-sectional design and results are based on hormone measurements in a blood sample collected at a single time point
Exposure Investigated
Exposures investigated
BMI and height
How exposure was measured
Questionnaire, self-administered
Exposure assessment comment
Anthropometric data self-reported
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Adequately controlled, Confounders: assay batch, date of collection, time of collection, age at collection, and BMI
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
Results Comments
BMI and weight were positively associated with estrogens and testosterone and inversely associated with SHBG Height was not associated with estrogens, androgens, or SHBG
Author address
Extramural Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA. lamarc@mail.nih.gov