Evidence From Humans
 
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Polychlorinated biphenyls, cytochrome P4501A1 polymorphism, and postmenopausal breast cancer risk
Moysich, K. B., Shields, P. G., Freudenheim, J. L., Schisterman, E. F., Vena, J. E., Kostyniak, P., Greizerstein, H., Marshall, J. R., Graham, S., Ambrosone, C. B. Cancer Epidemiology, Biomarkers & Prevention. 1999. 8:1, 41-4.
Topic area
Environmental pollutant - Genetic variability
Study design
Population based case-control
Funding agency
NCI, NIEHS
Study Participants
Menopausal Status
The menopausal status of women included in this study is listed here.
Post meopausal
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
In: Participants of the Western New York Breast Cancer Study. Cases were incident, primary, histologically confirmed breast cancers. Frequency matched to cases by age and county of residence from NYS DMV lists and Health Care Finance Administration Rolls.
Exposures investigated
Lipid adjusted total PCB; subgroups of PCB congeners; allele frequencies of CYP1A1 m2 variant, used PCR RFLP
How exposure was measured
Biological Questionnaire, in person
Statistical Analysis
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
No
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Adequately controlled
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
Yes
Description of major analysis
Logistic regression analysis of CYP1A1 frequencies and cancer risk, including effect modification by PCB level
Strength of associations reported
No significant association of PCB or genotype with BC risk
Postmenopausal women with m2 variant and high PCB levels (greater than control median) yielded an AOR=2.9 (1.18-7.45) when compared to women with wildtype genotype and low PCB exposure
Secondary analysis of subset of high-CYP1A1 inducible PCB congeners and variant genotype yielded AOR=2.87 (1.19-7.30); Highly estrogenic subset of PCB congeners and variant genotype yielded AOR=2.75 (1.09-7.21)
Results Comments
Included analysis of specific congener subgroupings based on PCB structure-behavior relationships
Author address
Department of Social and Preventive Medicine, SUNY-Buffalo, New York 14214, USA. kmoysich@sc3103.med.buffalo.edu
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