Environment and Breast Cancer: Science Review
About
Associations of weight, weight change, and body mass with breast cancer risk in Hispanic and non-Hispanic white women
Wenten, M., Gilliland, F. D., Baumgartner, K., Samet, J. M. Annals of Epidemiology. 2002. 12:6, 435-4.
Topic area
Body size - Physical Activity
Body size - Physical Activity
Study design
Population based case-control
Population based case-control
Funding agency
NCI
NCI
Study Participants
Number of Cases
712 (380 non-Hispanic whites) (332 Hispanics) (invasive or in situ only)
712 (380 non-Hispanic whites) (332 Hispanics) (invasive or in situ only)
Menopausal Status
Post menopausal
The menopausal status of women included in this study is listed here.
Pre menopausalPost menopausal
Number of Controls
Control: 844
Control: 844
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
In: participants of the New Mexico Women's Health Study; age 30-74 years; diagnosed with invasive or in situ breast cancer between 1/1/92 and 12/31/94 (cases); residents of New Mexico; women who completed a telephone screening interview (controls)
Ex: women with incomplete interview; women who moved out of the state during the study period
Comment about participation selection
Strengths: fairly large population based study; analyzed the relationship between breast cancer and body size in Hispanics who have had an 80% increase in obesity prevalence from 1991 to 1998; conducted in-person interviews; high participation rate amongst controls; stratified breast cancer analysis by menopausal status and ethnicity; calculated energy expenditure through metabolic equivalents (METs) Limitations: anthropometric data and non-occupational physical activity were self-reported; fairly low participation rate amongst Hispanic cases (68%)
Strengths: fairly large population based study; analyzed the relationship between breast cancer and body size in Hispanics who have had an 80% increase in obesity prevalence from 1991 to 1998; conducted in-person interviews; high participation rate amongst controls; stratified breast cancer analysis by menopausal status and ethnicity; calculated energy expenditure through metabolic equivalents (METs) Limitations: anthropometric data and non-occupational physical activity were self-reported; fairly low participation rate amongst Hispanic cases (68%)
Exposure Investigated
Exposures investigated
Height, physical activity, BMI, BMI at 18 years, weight at 18 years, weight change from 18 years, % weight change
Height, physical activity, BMI, BMI at 18 years, weight at 18 years, weight change from 18 years, % weight change
How exposure was measured
Questionnaire, in person
Questionnaire, in person
Exposure assessment comment
Anthropometric data were self-reported
Anthropometric data were self-reported
Breast cancer outcome investigated
Primary breast cancer
Primary breast cancer
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
Non-Hispanic Whites
Hispanic Americans
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Adequately controlled, confounders: age, family history of breast cancer, total METS, parity, oral contraceptive use, months of breast feeding, age at first full term pregnancy, weight at 18, HRT use, menopausal status
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
No
Description of major analysis
Effect modifiers: menopausal status and ethnicity
Effect modifiers: menopausal status and ethnicity
Strength of associations reported
Results denoted as "crude" by authors are age-adjusted.
Association between breast cancer and physical activity in Hispanic women, >60 METS vs. 0-20, OR=0.37(0.24-0.57) (crude)
Association between breast cancer and physical activity in non-Hispanic White women, >60 METS vs. 0-20, OR=0.69(0.46-1.02) (crude)
Association between breast cancer and height in Hispanic women, >167.6 cm vs. <157.4 cm, OR=1.51(0.88-2.61) (crude)
Association between breast cancer and height in non-Hispanic White women, >167.6 cm vs. <157.4 cm, OR=1.09(0.64-1.87) (crude)
Association between premenopausal breast cancer and BMI in Hispanic women, >30 vs. <22, OR=1.64(0.52-5.11) trend p=0.54
Association between postmenopausal breast cancer and BMI in Hispanic women, >30 vs. <22, OR=1.32(0.47-3.72) trend p=0.58
Association between breast cancer and BMI in Hispanic women, >30 vs. <22, OR=1.89(1.02-3.50) trend p=0.06
Association between premenopausal breast cancer and BMI in non-Hispanic White women, >30 vs. <22, OR=0.71(0.19-2.63) trend p=0.42
Association between postmenopausal breast cancer and BMI in non-Hispanic White women, >30 vs. <22, OR=2.77(0.86-8.89) trend p=0.16
Results denoted as "crude" by authors are age-adjusted.
Association between breast cancer and physical activity in Hispanic women, >60 METS vs. 0-20, OR=0.37(0.24-0.57) (crude)
Association between breast cancer and physical activity in non-Hispanic White women, >60 METS vs. 0-20, OR=0.69(0.46-1.02) (crude)
Association between breast cancer and height in Hispanic women, >167.6 cm vs. <157.4 cm, OR=1.51(0.88-2.61) (crude)
Association between breast cancer and height in non-Hispanic White women, >167.6 cm vs. <157.4 cm, OR=1.09(0.64-1.87) (crude)
Association between premenopausal breast cancer and BMI in Hispanic women, >30 vs. <22, OR=1.64(0.52-5.11) trend p=0.54
Association between postmenopausal breast cancer and BMI in Hispanic women, >30 vs. <22, OR=1.32(0.47-3.72) trend p=0.58
Association between breast cancer and BMI in Hispanic women, >30 vs. <22, OR=1.89(1.02-3.50) trend p=0.06
Association between premenopausal breast cancer and BMI in non-Hispanic White women, >30 vs. <22, OR=0.71(0.19-2.63) trend p=0.42
Association between postmenopausal breast cancer and BMI in non-Hispanic White women, >30 vs. <22, OR=2.77(0.86-8.89) trend p=0.16
Controls participation rate
Greater than 70% (81.2%)
Greater than 70% (81.2%)