Evidence From Humans
 
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Reproductive and anthropometric factors in relation to the risk of lobular and ductal breast carcinoma among women 65-79 years of age
Li, C. I., Malone, K. E., Porter, P. L., Weiss, N. S., Tang, M. T., Daling, J. R. International Journal of Cancer. 2003. 107:4, 647-51.
Topic area
Body size
Study design
Population based case-control
Study Participants
Number of Cases
975 (Invasive only) (656 ductal) (196 lobular) (123 other)
Menopausal Status
The menopausal status of women included in this study is listed here.
Post menopausal
Number of Controls
Controls: 1,007 Health Care Financing Administration (HCFA)
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
In: Age at baseline 65-79 yrs, lived in a 3 county Seattle-Puget Sound area at baseline, and diagnosed with invasive breast cancer between 4/97 and 5/99 Ex: Previous history of in situ or invasive breast cancer
Comment about participation selection
Strengths: Study included women of different races, focused on the different breast cancer histologies, conducted in-person interviews Limitations: Relied on diagnoses made by numerous pathologists, small number of lobular breast cancer cases, only 80.6% of eligible cases and 73.8% of eligible controls participated, body measurment data were based on self reports, only women 65-79 years of age participated
Exposure Investigated
Exposures investigated
Height, Weight, Weight at age 30, Maximum Weight, BMI
How exposure was measured
Questionnaire, in person
Exposure assessment comment
Body measurement data based on self reports
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
No
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Adequately controlled, Confounders: age and income
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
No
Strength of associations reported
Association between invasive breast cancer risk and height, > 170 vs <160 cm, OR=1.6(1.2-2.1) trend p < 0.05
Association between ductal breast cancer risk and height, > 170 vs <160 cm, OR=1.6(1.2-2.2) trend p < 0.05
Association between lobular breast cancer risk and height, > 170 vs <160 cm, OR=1.8(1.0-3.1) trend p <0.05
Association between invasive breast cancer risk and weight, >175 vs <130 lbs, OR=1.5(1.2-2.0) trend p < 0.05
Association between ductal breast cancer risk and weight, >175 vs <130 lbs, OR=1.5(1.2-2.0) trend p < 0.05
Association between invasive breast cancer risk and BMI, >30.12 vs. <23.32, OR=1.4(1.0-1.8) trend p < 0.05
Association between ductal breast cancer risk and BMI, >30.12 vs. <23.32, OR=1.4(1.0-1.9) trend p < 0.05
Author address
Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA 98109, USA. cili@fhcrc.org
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