Environment and Breast Cancer: Science Review
About
Lack of association of the codon 12 polymorphism of the peroxisome proliferator-activated receptor gamma gene with breast cancer and body mass
Memisoglu, A., Hankinson, S. E., Manson, J. E., Colditz, G. A., Hunter, D. J. Pharmacogenetics. 2002. 12:8, 597-603.
Topic area
Body size - Genetic variability
Body size - Genetic variability
Study design
Nested case-control study
Nested case-control study
Funding agency
NIH, NCI
NIH, NCI
Study Participants
Number of Cases
725
725
Menopausal Status
Post menopausal
The menopausal status of women included in this study is listed here.
Pre menopausalPost menopausal
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
Women in the Nurses' Health Study. Confirmed incident cases. Cohort controls matched on age, menopausal status, postmenopausal hormone use, time/month/fasting at blood draw
Exposures investigated
BMI, PPAR-γ allele frequencies, used PCR-RFLP
BMI, PPAR-γ allele frequencies, used PCR-RFLP
How exposure was measured
Biological Questionnaire, self-administered
Biological Questionnaire, self-administered
Breast cancer outcome investigated
Primary breast cancer
Primary breast cancer
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
No
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Adequately controlled
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
Yes
Description of major analysis
Logistic regression analysis of PPAR-γ genotype and breast cancer, including effect modification by BMI
Logistic regression analysis of PPAR-γ genotype and breast cancer, including effect modification by BMI
Strength of associations reported
PPAR-γ not related to BC risk
Compared to homozygous wildtype (Pro/Pro), fully adjusted OR=1.04 (CI: 0.80-135) among combined heterozygotes (Pro/Ala) and homozygotes (Ala/Ala)
Genotype did not show relation to BC risk across strata of BMI (data not shown)
PPAR-γ not related to BC risk
Compared to homozygous wildtype (Pro/Pro), fully adjusted OR=1.04 (CI: 0.80-135) among combined heterozygotes (Pro/Ala) and homozygotes (Ala/Ala)
Genotype did not show relation to BC risk across strata of BMI (data not shown)
Controls participation rate
Not reported
Not reported