Environment and Breast Cancer: Science Review

Evidence From Humans
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Regional assessment of atrazine exposure and incidence of breast and ovarian cancers in Kentucky
Hopenhayn-Rich, C., Stump, M. L., Browning, S. R. Archives of Environmental Contamination and Toxico. 2002. 42:1, 127-36.
Topic area
Environmental pollutant - Pesticide, atrazine, drinking water
Study design
Other: Ecologic epidemiology
Funding agency
Other: NIOSH
Study Participants
Number of Cases
120 counties, 15 area development districts
Menopausal Status
The menopausal status of women included in this study is listed here.
Pre menopausal
Post menopausal
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
Incident breast cancers diagnosed in 1993-1997
Exposure Investigated
Exposures investigated
Atrazine via drinking water. Quartile of public drinking water atrazine levels, acreage of corn planted, and atrazine sales.
How exposure was measured
GIS/geographic location Environmental sample
Breast cancer outcome investigated
Primary breast cancer: age-adjusted breast cancer incidence
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
African Americans
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Ecologic indicators: median household income, % population over age 25 with 4-year college education, % black residents
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
Description of major analysis
Poisson regression
Strength of associations reported
Adjusted relative risks are near one.
Author address
Department of Preventive Medicine and Environmental Health, University of Kentucky College of Medicine, 1141 Red Mile Rd. Suite 202, Lexington, Kentucky 40504, USA. cmhope0@pop.uky.edu