Environment and Breast Cancer: Science Review

Evidence From Humans
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Plasma concentrations of polychlorinated biphenyls and the risk of breast cancer: a congener-specific analysis
Demers, A., Ayotte, P., Brisson, J., Dodin, S., Robert, J., Dewailly, E. American Journal of Epidemiology. 2002. 155:7, 629-35.
Topic area
Environmental pollutant - Organochlorine, PCB
Study design
Hospital based case-control
Study Participants
Menopausal Status
The menopausal status of women included in this study is listed here.
Pre menopausal
Post menopausal
Number of Controls
Controls: 523
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
Hospital controls were admitted for non-cancer surgeries. Population controls were recruited from a state insurance database.
Exposures investigated
Plasma lipid concentrations of various PCB congeners.
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Age, region of residence, BMI, history of BBD, breastfeeding duration.
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
Description of major analysis
ORs were calculated using unconditional logistic regression. ORs were stratified by menopausal status.
Strength of associations reported
Significantly elevated risks were seen for the highest exposure quartiles of PCB congeners 118 and 156, and the total concentration of the mono-ortho congeners (105, 118, 156). In all three cases, substantially higher ORs were seen for pre-menopausal women than post-menopausal (only the pre-menopausal ORS were significantly elevated).
Author address
Department of Preventive Oncology and Epidemiology, CancerCare Manitoba, Winnipeg, Manitoba, Canada.
Controls participation rate
89% for hospital controls 47% for population contr