Environment and Breast Cancer: Science Review
About
Sulfotransferase 1A1 polymorphism, endogenous estrogen exposure, well-done meat intake, and breast cancer risk
Zheng, W., Xie, D., Cerhan, J. R., Sellers, T. A., Wen, W., Folsom, A. R. Cancer Epidemiology, Biomarkers and Prevention. 2001. 10:2, 89-94.
Topic area
Body size - Genetic variability
Body size - Genetic variability
Study design
Nested case-control study
Nested case-control study
Funding agency
NIH, USPHS
NIH, USPHS
Study Participants
Number of Cases
155
155
Menopausal Status
The menopausal status of women included in this study is listed here.
Post menopausal
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
Participants of the Iowa Women's Health Study. Prevalent cases identified through cancer registry of Iowa’s State Health registry. Random selection of cohort members without cancer diagnosis.
Comment about participation selection
Prevalent cases used
Prevalent cases used
Exposures investigated
BMI/WHR, SULT1A1 allele frequencies, used PCR-RFLP
BMI/WHR, SULT1A1 allele frequencies, used PCR-RFLP
How exposure was measured
Biological Questionnaire, self-administered
Biological Questionnaire, self-administered
Breast cancer outcome investigated
Primary breast cancer
Primary breast cancer
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
No
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Adequately controlled
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
Yes
Description of major analysis
Logistic regression analysis of SULT1A1 genotype and breast cancer, including effect modification by BMI/WHR
Logistic regression analysis of SULT1A1 genotype and breast cancer, including effect modification by BMI/WHR
Strength of associations reported
In full sample, significant trend for increasing number of His alleles (p=.027); Adjusted OR=1.8 (CI:1-3.2) for homozygous genotype and OR=1.4 (CI:0.9-2.2) for heterozygous genotype
Stratification by BMI showed significant increase in risk for women with higher BMI and low activity homozygous (His) genotype; BMI <26.18 and heterozygous genotype yielded an OR=1.3 (CI: 0.7-2.5) and homozygous OR=1.1 (CI: 0.5-2.6); BMI>=26.18 yielded OR=1.5 (CI: 0.8-2.7) and OR=2.9 (CI: 1.3-6.5); p<.01 for trend in BMI>=26.18 group
In full sample, significant trend for increasing number of His alleles (p=.027); Adjusted OR=1.8 (CI:1-3.2) for homozygous genotype and OR=1.4 (CI:0.9-2.2) for heterozygous genotype
Stratification by BMI showed significant increase in risk for women with higher BMI and low activity homozygous (His) genotype; BMI <26.18 and heterozygous genotype yielded an OR=1.3 (CI: 0.7-2.5) and homozygous OR=1.1 (CI: 0.5-2.6); BMI>=26.18 yielded OR=1.5 (CI: 0.8-2.7) and OR=2.9 (CI: 1.3-6.5); p<.01 for trend in BMI>=26.18 group
Controls participation rate
Greater than 70%
Greater than 70%