Environment and Breast Cancer: Science Review

Evidence From Humans
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Molecular significance of excess body weight in postmenopausal breast cancer patients, in relation to expression of insulin-like growth factor I receptor and insulin-like growth factor II genes
Suga, K., Imai, K., Eguchi, H., Hayashi, S., Higashi, Y., Nakachi, K. Japanese Journal of Cancer Research. 2001. 92:2, 127-34.
Topic area
Body size
Study design
Other: case analysis
Funding agency
Other: Ministry of Education, Science, Sports, and
Study Participants
Number of Cases
106 (63 pre) (43 post)
Menopausal Status
The menopausal status of women included in this study is listed here.
Pre menopausal
Post menopausal
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
In: Breast cancer cases who had tissue specimens collected at the Saitama Cancer Center Hospital
Comment about participation selection
Strengths: conducted in-person interviews; analyzed expression levels of Insulin-like Growth factor I receptor (IGF-IR), Insulin-like Growth factor I (IGF-I), Insulin-like Growth factor 2 (IGF-2) stratified by menopausal status and BMI in normal and breast cancer tissues of breast cancer cases. Limitations: few cases studied; does not compare IGF levels to a control group; ORs were not examined in this study since there was no control group; does not state how anthropometric measurements were obtained
How exposure was measured
Questionnaire, in person
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
Japanese Women
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Adequately controlled, confounders: none (ORs were not examined in this study since there was no control group)
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
Results Comments
Significant and positive association between IGF-IR and IGF-2 in normal tissue and increased BMI (>24) among postmenopausal breast cancer cases. Positive association between IGF-IR in breast cancer tissue and increased BMI (>24) among postmenopausal breast cancer cases.
Author address
Department of Transfusion Medicine, Saga Medical School Hospital, Saga 849-8501, Japan. sugak@post.saga-med.ac.jp