Environment and Breast Cancer: Science Review

Evidence From Humans
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Polymorphic catechol-O-methyltransferase gene and breast cancer risk
Mitrunen, K., Jourenkova, N., Kataja, V., Eskelinen, M., Kosma, V. M., Benhamou, S., Kang, D., Vainio, H., Uusitupa, M., Hirvonen, A. Cancer Epidemiology, Biomarkers and Prevention. 2001. 10:6, 635-40.
Topic area
Body size - Genetic variability
Study design
Population based case-control
Funding agency
Academy of Finland, Finnish Konkordia Foundation,
Study Participants
Menopausal Status
The menopausal status of women included in this study is listed here.
Pre menopausal
Post menopausal
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
Cases were physician-referred, newly diagnosed, histologically confirmed incident cases; participants of the Kuopio Breast Cancer Study. Controls were breast disease-free population controls from the Finnish National Population Register in same catchment area as cases.
Exposures investigated
BMI, Allele frequencies of COMT, used PCR-RFLP
How exposure was measured
Biological Questionnaire, in-person
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Adequately controlled
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
Description of major analysis
Logistic regression analysis of COMT genotype and cancer risk, including effect modification by BMI
Strength of associations reported
COMT-L genotype associated with decreased risk in women with premenopausal advanced disease, and COMT-LL associated with decreased risk in postmenopausal women with local disease
BMI showed effect modification, with postmenopausal women with COMT-LL genotype and BMI <= 25.4 showing decreased risk (OR=0.33, CI: 0.13-0.83)
Controls participation rate
Greaster than 70%