Environment and Breast Cancer: Science Review

Evidence From Humans
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Proportionate mortality among US migrant and seasonal farmworkers in twenty-four states
Colt, J. S., Stallones, L., Cameron, L. L., Dosemeci, M., Zahm, S. H. American Journal of Industrial Medicine. 2001. 40:5, 604-11.
Topic area
Environmental pollutant - Pesticide
Study design
Other: Cohort proportional mortality
Study Participants
Menopausal Status
The menopausal status of women included in this study is listed here.
Pre menopausal
Post menopausal
Number of Controls
1081 white women, 3137 nonwhite women
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
Deaths in 24 US states in 1984-1993
Comment about participation selection
Texas, California, and Florida are not included. These are the states where most farmworkers live when they are not migrating, so primarily deaths away from home are included. Retired farmworkers unlikely to be included.
Exposure Investigated
Exposures investigated
employment as a farmworker from usual occupation on death certificate
Statistical Analysis
Breast cancer outcome investigated
Mortality from breast cancer
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
White, nonwhite
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Race, age, region
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
Description of major analysis
Proportionate mortality
Strength of associations reported
Significant deficit; PMR = 82 (95% CI 68-99)
Results Comments
Significant methodological limitations discussed above.
Author address
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892-7240, USA. coltj@mail.nih.gov