Environment and Breast Cancer: Science Review

Evidence From Humans
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Hypertension and breast cancer risk in a 19-year follow-up study (the DOM cohort). Diagnostic investigation into mammarian cancer
Peeters, P. H., van Noord, P. A., Hoes, A. W., Fracheboud, J., Gimbrere, C. H., Grobbee, D. E. Journal of Hypertension. 2000. 18:3, 249-54.
Topic area
Body size
Study design
Prospective cohort
Funding agency
Not reported
Study Participants
Menopausal Status
The menopausal status of women included in this study is listed here.
Post menopausal
Number in Cohort
Cohort: 11,011
Cohort participation rate
Retention/participation exceeded 70% for exposed a
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
In: resident of Utrech, Netherlands, part of the DOM Cohort, age 50-65 years at baseline, attended screening rounds between 1974 and 1985 in Utrecht Ex: women diagnosed with breast cancer within one year of recruitment
Comment about participation selection
Strengths: One of the few studies that assessed hypertension and breast cancer risk; lengthy follow up of 19 years (median); anthropometric data measured by trained nurses Limitations: prevalence of hypertension in the study population was high compared to other Netherlands population studies; measurement error could have caused an over estimation of hypertension prevalence
Exposures investigated
Height, BMI, and weight
How exposure was measured
Questionnaire, self-administered Anthropometric measurement, researcher-administered by trained nurses at baseline examination
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Adequately controlled, Confounders: age, BMI, height, parity, familial breast cancer, smoking habits, and OC use
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
Description of major analysis
Effect Modifiers: anti-hypertensive drug use
Results Comments
Results do not support an association between breast cancer and hypertension. If there is a link it is likely to be positive and relatively small in size.
Author address
Julius Center for Patient Oriented Research, University Medical Center, Utrecht, The Netherlands. P.H.M.Peeters@jc.acu.nl