Environment and Breast Cancer: Science Review

Evidence From Humans
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Organochlorine exposure and breast cancer survival
Hoyer, A. P., Jorgensen, T., Brock, J. W., Grandjean, P. Journal of Clinical Epidemiology. 2000. 53:3, 323-30.
Topic area
Environmental pollutant - Pesticides, organochlorine, PCB, DDT, DDE, beta-HC
Study design
Other: Case-case survival analysis
Study Participants
Menopausal Status
The menopausal status of women included in this study is listed here.
Pre menopausal
Post menopausal
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
Cases were women who developed breast cancer after their first examination by the Copenhagen City Heart Study.
Exposures investigated
Serum lipid-adjusted concentrations of beta-HCH, HCB, Dieldrin, PCBs, DDE, and DDT.
Breast cancer outcome investigated
Mortality from breast cancer
Breast cancer recurrence or progression
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Age, tumor characteristics, time from blood sampling to diagnosis.
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
Description of major analysis
Cox proportional hazard modeling was used for the survival analysis.
Strength of associations reported
Dieldrin was the compound most strongly associated with decreased survival, regardless of the type of adjustments for confounding. The association was strengthened when repeated measures of exposure were averaged. DDT only showed a significant association when the repeated measures were used.
Author address
The Center of Preventive Medicine, KAS Glostrup, Denmark and Copenhagen Center for Prospective Population Studies, Frederiksberg C, Denmark. APH@Post8.tele.dle