Environment and Breast Cancer: Science Review

Evidence From Humans
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Elevated risk for male breast cancer after occupational exposure to gasoline and vehicular combustion products
Hansen, J. American Journal of Industrial Medicine. 2000. 37:4, 349-52.
Topic area
Environmental pollutant - Male breast cancer, occupation, PAH, benzene, orga
Study design
Other: Registry based case-control
Study Participants
Menopausal Status
The menopausal status of women included in this study is listed here.
Number of Controls
Controls: 12,880
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
Cases were male employees born between 1897 -1966 who were members of the national Pension Fund diagnosed with a first primary breast cancer in 1970-1989, as identified from the Danish Cancer Registry.
Exposures investigated
Gasoline and vehicular combustion products; benzene; 1,3-butadiene; 1,2-dibromoethane; 1,2 dichloroethane; PAHs. Duration of exposed work. Blue collar workers who had over 3 months employment in companies with trade codes of service station, vehicle main
Breast cancer outcome investigated
Primary breast cancer: male
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Socioeconomic status
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
Description of major analysis
Conditional logistic regression; 10-year exposure lag to account for latency
Strength of associations reported
exposed vs. unexposed with no lag time:
OR = 2.2 (95% CI 1.4-3.6); for age < 40 at first exposure, OR = 3.7 (1.7-7.9); for age 40-66 at first exposure OR = 1.7 (0.9-3.4)
exposed vs. unexposed with >10 years lag time:
OR = 2.5 (1.3-4.5); for age < 40 at first exposure, OR = 5.4 (2.4-11.9); for age 40-66 at first exposure OR = 1.2 (0.4-3.3)

Author address
Danish Cancer Society, Institute of Cancer Epidemiology, Strandboulevarden 49, DK-2100 Copenhagen o, Denmark. johni@cancer.dk