Evidence From Humans
 
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Polychlorinated biphenyls and breast cancer risk by combined estrogen and progesterone receptor status
Rusiecki, J. A., Holford, T. R., Zahm, S. H., Zheng, T. European Journal of Epidemiology. 2004. 19:8, 793-801.
Topic area
Environmental pollutant - Organochlorine, PCB
Study design
Hospital based case-control
Study Participants
Menopausal Status
The menopausal status of women included in this study is listed here.
Pre menopausal
Post menopausal
Number of Controls
Controls: 186
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
Controls were patients undergoing breast surgery but who were diagnosed either with benign breast disease, or normal breast tissue.
Exposures investigated
Breast adipose tissue and serum concentrations of PCBs (lipid-adjusted).
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
No
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Age, age at menarche, breastfeeding period, BMI, parity, age at first birth, family history of breast cancer.
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
No
Description of major analysis
Multiple logistic regression.
Strength of associations reported
No elevated risks were seen for any ER/PR combination for congeners 187, 74, 118, 138, 156, 170, 153, or 180. Among postmenopausal women, an association was only seen for ER+/PR+ tumors for BZ-183 (highest tertile OR = 2.4, 1.0-6.0).
Author address
Department of Epidemiology and Public Health, Yale University School of Medicine, USA. rusieckj@mail.nih.gov
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