Evidence From Humans
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Is family history of breast cancer a marker of susceptibility to exposures in the incidence of de novo adult acute leukemia?
Rauscher, G. H., Sandler, D. P., Poole, C., Pankow, J., Shore, D., Bloomfield, C. D., Olshan, A. F. Cancer Epidemiol Biomarkers Prev. 2003. 12:4, 289-94.
Topic area
Environmental pollutant - Occupation, PAH, organic solvents
Study design
Population based case-control
Study Participants
Menopausal Status
The menopausal status of women included in this study is listed here.
Not reported
Number of Controls
Controls: 625
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
Adult leukemia patients and controls
Exposures investigated
Self-reported home or occupational use of specific solvents and aromatic hydrocarbons
How exposure was measured
Questionnaire, by telephone
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
Results Comments
Leukemia risk was elevated in association with a family history of breast cancer. Exposed participants with family history of breast cancer: leukemia RR 1.9 (1.1-3.4). Sibling with breast cancer: leukemia RR 3.7 (1.2-11). Aromatic hydrocarbon exposure and family history of breast cancer: leukemia RR 3.8 (1.1-14)
Author address
Division of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, Illinois 60612, USA. garthr@uic.edu
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