Environment and Breast Cancer: Science Review

Evidence From Humans
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Breast cancer risk associated with genotype polymorphism of the estrogen-metabolizing genes CYP17, CYP1A1, and COMT: a multigenic study on cancer susceptibility
Huang, C. S., Chern, H. D., Chang, K. J., Cheng, C. W., Hsu, S. M., Shen, C. Y. Cancer Research. 1999. 59:19, 4870-5.
Topic area
Body size - Genetic variability
Study design
Hospital based case-control study
Funding agency
Not specified
Study Participants
Menopausal Status
The menopausal status of women included in this study is listed here.
Pre menopausal
Post menopausal
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
Pathologically confirmed primary breast cancer cases recruited from university hospital. Controls were a random sample of women from clinic in same hospital during same study period, free of all cancers.
Exposures investigated
BMI, Allele frequencies of COMT, CYP1A1, and CYP17, used PCR-RFLP
How exposure was measured
Biological Questionnaire, in-person
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Adequately controlled
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked Yes. No, if not.
Description of major analysis
Logistic regression analysis of high risk genotypes and breast cancer, including effect modification by BMI
Strength of associations reported
COMT-LL, CYP17 A2/A2, and CYP1A1 MspI vt/vt were considered “high risk”
High risk COMT-LL showed strongest relationship to BC risk, followed by high risk CYP1A1 and then CYP17
In a model in which the three genetic risk factors were entered simultaneously, only COMT showed a significant association (OR=4.02, CI: 1.12-19.08)
Having any two out of three putative high-risk genotypes showed an adjusted OR=3.52 (CI: 1.06-12.4) whereas having only one showed OR=1.47 (CI: 0.81-2.66) Analysis of having any one high risk genotype stratified by BMI showed BMI <22.5 yielding an OR=1.42 (CI: 0.78-2.68) whereas BMI>=22.5 OR=1.91 (CI: 1.07-3.66)