Environment and Breast Cancer: Science Review

Evidence From Humans
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Serum Concentrations of Organochlorine Compounds and the Subsequent Development of Breast Cancer
Helzlsouer, Kathy J., Alberg, Anthony J., Huang, Han-Yao, Hoffman, Sandra C., Strickland, Paul T., Brock, John W., Burse, Virlyn W., Needham, Larry L., Bell, Douglas A., Lavigne, Jackie A., Yager, James D., Comstock, George W. Cancer Epidemiol Biomarkers Prev. 1999. 8:6, 525-532.
Topic area
Environmental pollutant - Genetic variability
Study design
Nested case-control
Funding agency
NCI; DOD; NIEHS; National Heart, Lung, and Blood I
Study Participants
Menopausal Status
The menopausal status of women included in this study is listed here.
Pre menopausal
Post menopausal
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
CLUE I, CLUE II. Cases were cohort members who had donated blood and were identified by cancer registry. Controls were cohort members who had donated blood and were matched to case member.
Comment about participation selection
Sample used in current analysis represents small percentage of overall sample from two cohorts
Exposures investigated
Lipid adjusted total PCB and DDE; allele frequencies for GSTM1, GSTT1, GSTP1, COMT, and CYP17, used PCR
How exposure was measured
Biological Questionnaire, in person
Statistical Analysis
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Difficult to assess because of small sample size
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked Yes. No, if not.
Description of major analysis
Logistic regression analysis of allele frequencies and PCB level on cancer risk; limited interaction analyses
Strength of associations reported
No increase in BC risk noted for higher levels of either PCB or DDE exposure
Risk estimates for gene environment interactions did not include CI’s, and based on very small numbers;Most p-values for trends were non-significant
Results Comments
Difficult to draw conclusions of gene environment interaction analyses because of limited data reported