Evidence From Humans
 
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Breast cancer risk factors: PCB congeners
Lucena, R. A., Allam, M. F., Costabeber, I. H., Villarejo, M. L., Navajas, R. F. European Journal of Cancer Prevention. 2001. 10:1, 117-9.
Topic area
Environmental pollutant - Organochlorine, PCB
Study design
Hospital based case-control
Study Participants
Menopausal Status
The menopausal status of women included in this study is listed here.
Pre menopausal
Post menopausal
Number of Controls
Controls: 65
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
All women undergoing surgery for breast lumps in one hospital were included. Controls were those with benign tumors.
Exposures investigated
Breast adipose tissue concentrations of PCB congeners.
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
No
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Age, smoking, alcohol consumption, parity, lactation period, overweight.
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
No
Description of major analysis
Multivariable logistic regression.
Strength of associations reported
A significantly elevated OR of 9.6 (95% CI: 2.8-24.2) was found for PCB congener 28.
Author address
Department of Preventive Medicine and Public Health, Faculty of Medicine, University of Cordoba, Spain. srlanlum@lucano.uco.es
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