Environment and Breast Cancer: Science Review

Evidence From Humans
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Fatty-acid composition in serum phospholipids and risk of breast cancer: an incident case-control study in Sweden
Chajes, V., Hulten, K., Van Kappel, A. L., Winkvist, A., Kaaks, R., Hallmans, G., Lenner, P., Riboli, E. Int J Cancer. 1999. 83:5, 585-90.
Study design
Nested case-control
Funding agency
Not reported
Study Participants
Menopausal Status
The menopausal status of women included in this study is listed here.
Post menopausal and premenopausal combined
Number in Cohort
Controls: 388/ cohort: 47194
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
In: Women participating in one of the three cohort studies: VIP (Vasterbotten Intervention Project), MONICA (Monitoring of Trends in Cardiovascular Disease), MSP (Mammary Screening Project) Ex: Lack of blood sample
Comment about participation selection
Mix of women recruited from 3 different cohort studies, eligible criteria not given, mean length of follow-up very short
Exposure Investigated
Exposures investigated
Fatty acid (saturated, monounsaturated, n-6 PUFAs, n-3 PUFAs)
Exposure assessment comment
Not controlled for fasting time before blood sampling
Statistical Analysis
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Not considered: BMI, family history of breast cancer, race, menopausal status, alcohol consumption
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
Description of major analysis
Adjusted RR with 95% CI, highest vs lowest quartile of intake, menopausal status sub-group, mean follow-up not cited, 3 studies until May 1997, VIP: from 1985, MONICA from 1986-1990-1994, MSP from 1995
Strength of associations reported
Saturated: 1.15 (0.46-2.85), Monounsaturated 1.78 (0.81-3.92), n-6 PUFAs 0.91 (0.40-2.06), n-3 PUFAs 0.58 (0.27-1.28)
Results Comments
No significant association between n-3 PUFA and breast cancer risk. .
Author address
Laboratoire de Biologie des Tumeurs, E.A. 2103, Unite de Recherche Associee Universite-INRA, Faculte de Medecine, Tours, France.