Environment and Breast Cancer: Science Review

Evidence From Humans
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The relationship between breast asymmetry, breast size and the occurrence of breast cancer
Scutt, D., Manning, J. T., Whitehouse, G. H., Leinster, S. J., Massey, C. P. British Journal of Radiology. 1997. 70:838, 1017-21.
Topic area
Body size
Study design
Hospital based case-control
Funding agency
Other: Broadgreen University Hospital NHS Trust
Study Participants
Menopausal Status
The menopausal status of women included in this study is listed here.
Post menopausal
Number of Controls
Control: 250
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
In: Women who received cranio-caudal mammograms at the Breast Assessment Unit in Liverpool, and women age 50 to 75 years (postmenopausal)
Comment about participation selection
Strengths: Study focuses on breast asymmetry as a risk factor for breast cancer, and anthropometric data was taken directly from mammogram films (no bias) Limitations: Does not address any other exposures besides breast asymmetry
Exposure Investigated
Exposures investigated
Breast asymmetry
Exposure assessment comment
Lack of variation
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Adequately controlled, Confounders: none
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
Author address
Department of Medical Imaging, School of Biological Sciences, University of Liverpool, UK.