Environment and Breast Cancer: Science Review

Evidence From Humans
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Reversal of relation between body mass and endogenous estrogen concentrations with menopausal status.[see comment]
Potischman, N., Swanson, C. A., Siiteri, P., Hoover, R. N. Journal of the National Cancer Institute. 1996. 88:11, 756-8.
Topic area
Body size
Study design
Other: community and hospital based analysis of controls from an endometrial cancer study
Funding agency
Not reported
Study Participants
Menopausal Status
The menopausal status of women included in this study is listed here.
Pre menopausal
Post menopausal
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
In: participated in an endometrial cancer study Ex: women without BMI data; reported use of exogenous estrogens or oral contraceptives within 6 months; had hormone values that indicated Premarin usage or perimenopausal status
Comment about participation selection
Strengths: analyzed BMI by hormone levels by menopausal status, anthropometric measurements obtained by trained nurses and staff Limitations: does not asses breast cancer risk; only one blood sample obtained from each participant
How exposure was measured
Questionnaire, self-administered Anthropometric measurement, researcher-administered
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Adequately controlled, Confounders: adjusted for age
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
Strength of associations reported
Estradiol levels increased with increasing BMI among premenopausal women and decreased with increasing BMI among postmenopausal women.