Environment and Breast Cancer: Science Review

Evidence From Humans
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Dietary fat, calories, and the risk of breast cancer in postmenopausal women: a prospective population-based study
Barrett-Connor, E., Friedlander, N. J. J Am Coll Nutr. 1993. 12:4, 390-9.
Study design
Prospective cohort
Funding agency
National Institute of Diabetes, Digestive, and Kid
Study Participants
Menopausal Status
The menopausal status of women included in this study is listed here.
Postmenopausal only
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
In: Women who participated in a heart disease risk factor survey and who were invited for a more extensive evaluation (15% random sample of participants and 15% who were hyperlipidemic)
Comment about participation selection
The authors should have had separate analyses for the hyperlipidemic group of women and the rest of the participants.
Exposure Investigated
Exposures investigated
Total fat, total carbohydrates
How exposure was measured
Questionnaire, 24-hour dietary recall
Exposure assessment comment
No additional information is given for the 24 hour recall.
Ethnic groups with separate analysis
If this study provided a separate analysis by ethnic or racial group, the groups are listed here.
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Not considered: Family history of breast cancer
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
Description of major analysis
RR with 95% CI, continuous variables, follow-up from 1972 - 1987
Strength of associations reported
Total carbohydrate: 2.01 (1.19 - 3.41); total carbohydrate: 1.93 (1.18 - 3.16)
Author address
Dept. of Family and Preventive Medicine, University of California, San Diego, La Jolla 92093-0607.