Environment and Breast Cancer: Science Review

Evidence From Humans
Print this page
Effects of bisphenol A on breast cancer and its risk factors
Yang, M., Ryu, J. H., Jeon, R., Kang, D., Yoo, K. Y. Arch Toxicol. 2009. 83:3, 281-5.
Topic area
Environmental pollutant - BPA
Study design
Hospital based case-control
Funding agency
SRC program of KOSEF (Research Center for Women’
Study Participants
Menopausal Status
The menopausal status of women included in this study is listed here.
No analysis based on menopausal status
Number of Controls
Controls: 82
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
All subjects were patients at Seoul National University Hospital between 1994 and 1997; cases were those diagnosed with breast cancer for the first time. Controls were those who received negative diagnoses.
Comment about participation selection
Treatment status of cases not specified.
Exposure Investigated
Exposures investigated
Conjugated blood BPA levels collected from 1994-1997.
How exposure was measured
Biological Questionnaire
Exposure assessment comment
The authors chose to measure conjugated BPA instead of free BPA in order to limit sample contamination with BPA in collection and storage equipment. However, conjugated BPA is best measured in urine, according to Calafat et al. 2013.
Breast cancer outcome investigated
Primary incident breast cancer
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked “Yes.” “No”, if not.
Strength of associations reported
Median levels of conjugated BPA were non-significantly higher in cases (0.6 ug/L) than in controls (0.03).
Results Comments
Fifty-one percent of participants' results were non-detects, including ≥ 50% of controls. No other measures of association between BPA and breast cancer reported.
Author address
College of Pharmacy, Sookmyung Women's University, Chungpa-Dong, Yongsan-Gu, Seoul 140-742, Republic of Korea. myang@sm.ac.kr