Environment and Breast Cancer: Science Review

Evidence From Humans
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Integrated Bioinformatics, Environmental Epidemiologic and Genomic Approaches to Identify Environmental and Molecular Links between Endometriosis and Breast Cancer
Roy, D., Morgan, M., Yoo, C., Deoraj, A., Roy, S., Yadav, V. K., Garoub, M., Assaggaf, H., Doke, M. Int J Mol Sci. 2015. 16:10, 25285-322.
Topic area
Environmental pollutant - PCBs
Study design
Funding agency
Not reported
Study Participants
Number of Cases
Not reported
Menopausal Status
The menopausal status of women included in this study is listed here.
No analysis based on menopausal status
Number of Controls
Not reported
Country where study was conducted
This meta-analysis was conducted in the USA and re
Participant selection: Inclusion and exclusion criteria
Criteria used to select participants in the study.
Studies identified in PubMed and accepted according to the following criteria: original results published after year 200, in “scholarly publications”; reported exposure levels using medians, means, geometric means, or TEQs; estimated odds ratios and 95% CIs; did not assess exposure using GIS/geographic information; included at least four cases; and reported the time of exposure.
Comment about participation selection
All of the studies included in this analysis used a case-control design. The stop date for the PubMed search is not specified. The authors identified 10 studies of PCBs and breast cancer but only included six in the meta-analysis, it is not clear why four were left out.
Exposures investigated
Serum or plasma concentrations of PCBs
Breast cancer outcome investigated
Primary incident breast cancer
Confounders considered
Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were taken into account in the study.
Age and gender were controlled across studies. All studies controlled for at least one reproductive risk factor.
Genetic characterization included
If the study analyzed relationships between environmental factors and inherited genetic variations, this field will be marked Yes. No, if not.
Strength of associations reported
Meta-OR for total PCB exposure (sum of congeners, ng/g): aOR 1.33 (95% CI 0.72-2.65)
Results Comments
No meta-analysis was performed for exposure to BPA or phthalates because only one study for each chemical qualified for this review.
Author address
Department of Environmental & Occupational Health, Florida International University, Miami, FL 33199, USA. droy@fiu.edu. Department of Environmental & Occupational Health, Florida International University, Miami, FL 33199, USA. mmorg003@fiu.edu. Departmen
Reviewers Comments
It is not clear what congeners were included in the sum, total PCBs, or if the congeners getting summed were the same across studies.