Environment and Breast Cancer: Science Review
Cancer studies: Mammary gland tumors
Originating list
The list(s) or database(s) in which the chemical was identified as showing an
increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC:
International Agency for Research on Chemicals Monographs on the Evaluation of
Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program
(NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical
Carcinogenesis Research Information Service.
Carcinogenicity Potency Database, IARC Monographs, National Toxicology Program 11th Report on Carcinogens
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most
often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases,
supplemented by our evaluation of individual studies and reviews, is available for the priority
chemicals and 67 others.
One study noted slight mammary tumor increase.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man. Supplement 7: (1987) (p. 123) Benzidine.
Review
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man. VOL.: 29 (1982) (p. 149) Benzidine and its sulphate hydrochloride and dihydrochloride.
Review
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 1 (1972) (p. 80) Benzidine.
Review
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
National Toxicology Program 11th Report on Carcinogens. Benzidine and Dyes Metabolized to Benzidine
Review
Osanai, H. An experimental study on hepatoma caused by aromatic amines. J. Sci. Labour 52: 179-201(1976).
Primary Literature
Zabezhinskii MA. [The effect of the inhalation method of administering various atomized carcinogenic substances]. Biull Eksp Biol Med 1970;69(1):72-4
Huggins C, Briziarelli G, Sutton H, Jr. Rapid induction of mammary carcinoma in the rat and the influence of hormones on the tumors. J Exp Med 1959;109(1):25-42.
Primary Literature
Morton KC, Wang CY, Garner CD, Shirai T. Carcinogenicity of benzidine, N,N'-diacetylbenzidine, and N-hydroxy-N,N'-diacetylbenzidine for female CD rats. Carcinogenesis 1981;2(8):747-52.
Primary Literature
Pliss GB, Vol'fson NI. [Effect of ortho-tolidine on benzidine induction of tumors in rats]. Vopr Onkol 1974;20(2):53-7.
Primary Literature
Steinhoff D. [Intense carcinogenic effect of benzidine]. Naturwissenschaften 1974;61(6):276-7.
Primary Literature
National Toxicology Program 11th Report on Carcinogens,
Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review