Environment and Breast Cancer: Science Review


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IQ
CAS RN 76180-96-6



Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
Carcinogenicity Potency Database, IARC Monographs, National Toxicology Program 11th Report on Carcinogens, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
NTP 11th ROC: IQ administered orally caused mammary tumors in female rats.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man. VOL.: 56 (1993) (p. 165) IQ (2-amino-3-methylimidazo[4,5-f]quinoline)
Oral administration by gavage induced mammary tumors in female rats: Tanaka 1985.
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
One of five studies reports mammary tumors: Weisburger 1994. Four studies did not report mammary tumors: Ohgaki 1984, Adamson 1994, Guo 1995 and Ohgaki 1986.
National Toxicology Program 11th Report on Carcinogens. 2-Amino-3-Methylimidazo [4,5-f ]Quinoline (IQ).
Review
In rats, IQ administered orally caused mammary- and clitoral-gland tumors in females.
Weisburger JH, Rivenson A, Hard GC, Zang E, Nagao M, Sugimura T. Role of fat and calcium in cancer causation by food mutagens, heterocyclic amines. Proc Soc Exp Biol Med 1994;205(4):347-52.
Primary Literature
Adamson RH, Takayama S, Sugimura T, Thorgeirsson UP. Induction of hepatocellular carcinoma in nonhuman primates by the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline. Environ Health Perspect 1994;102(2):190-3.
Primary Literature
A study listed by CPDB 2005 that did not report mammary tumors.
Guo D, Horio DT, Grove JS, Dashwood RH. Inhibition by chlorophyllin of 2-amino-3-methylimidazo-[4,5-f]quinoline-induced tumorigenesis in the male F344 rat. Cancer Lett 1995;95(1-2):161-5.
Primary Literature
A study listed by CPDB 2005 that did not report mammary tumors.
Ohgaki H, Hasegawa H, Kato T, Suenaga M, Ubukata M, Sato S, et al. Carcinogenicity in mice and rats of heterocyclic amines in cooked foods. Environ Health Perspect 1986;67:129-34.
Primary Literature
A study listed by CPDB 2005 that did not report mammary tumors.
Ohgaki H, Kusama K, Matsukura N, Morino K, Hasegawa H, Sato S, et al. Carcinogenicity in mice of a mutagenic compound, 2-amino-3-methylimidazo[4,5-f]quinoline, from broiled sardine, cooked beef and beef extract. Carcinogenesis 1984;5(7):921-4.
Primary Literature
A study listed by CPDB 2005 that did not report mammary tumors.
Tanaka T, Barnes WS, Williams GM, Weisburger JH. Multipotential carcinogenicity of the fried food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in rats. Jpn J Cancer Res. 1985 Jul;76(7):570-6.
Primary Literature
From IARC