Environment and Breast Cancer: Science Review

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Key References
Abbreviations
 

1,3-dinitropyrene
CAS RN 75321-20-9

Chemical Summary
Exposure and Risk Assessment
Cancer Studies
 


Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
Structural similarity to other nitro-PAHs that cause mammary tumors. One positive study.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 46 (1989) (p. 201) 1,3-Dinitropyrene. Summary of Data Reported and Evaluation.
Review
Oral administration induced mammary tumors in female rats. [The Working Group noted the short duration of both treatment and observation and that, in parallel studies, positive results were obtained with 1,6- and 1,8-dinitropyrene]: King 1988. Subcutaneous administration induced mammary tumors in female rats: King 1988. Intraperitoneal administration induced mammary tumors in female rats. [The Working Group noted the high and variable spontaneous incidence of mammary tumors seen in these studies]: King 1988.
http://monographs.iarc.fr/ENG/Monographs/vol46/volume46.p...
National Library of Medicine. (CCRIS) Chemical Carcinogenesis Research Information System. [cited 2005 September 30]
Review
2 references total. 1 reference mentions mammary tumors. -HIROSE,M, MUTAI,M, TAKAHASHI,S, YAMADA,M, FUKUSHIMA,S AND ITO,N; EFFECTS OF PHENOLIC ANTIOXIDANTS IN LOW DOSE COMBINATION ON FORESTOMACH CARCINOGENESIS IN RATS PRETREATED WITH N-METHYL-N'-NITRO-N-NITROSOGUANIDINE; CANCER RES. 51(3):824-827, 1991
http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?CCRIS
King CM. Metabolism and biological effects of nitropyrene and related compounds. Res Rep Health Eff Inst. 1988 Feb(16):1-22.
Primary Literature
From IARC
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review
Not nominated for NTP testing in 1998-2003.
http://ntp.niehs.nih.gov/ntp/roc/eleventh/tab1.pdf