Environment and Breast Cancer: Science Review


Search the Mammary Carcinogens Reviews Database

vinyl fluoride
CAS RN 75-02-5



Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
Carcinogenicity Potency Database, IARC Monographs, National Toxicology Program 11th Report on Carcinogens, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
NTP 11th ROC: Female mice showed an increased incidence of mammary gland adenocarcinoma.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 63 (1995) (p. 467) Vinyl Fluoride.
Review
In one inhalation experiment, produced mammary tumors in female mice: Bogdanffy (1995) authors did not perform statistical analyses because of the differences in the times of killing in the various groups.
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
One of one studies reports mammary tumors. Bogdanffy 1995
National Toxicology Program 11th Report on Carcinogens. Vinyl Fluoride
Review
Female mice exposed by inhalation showed an increased incidence of mammary gland adenocarcinoma (Bogdanffy et al. 1995, IARC 1995). @@Bogdanffy, M. S., G. T. Makovec and S. R. Frame. 1995. Inhalation oncogenicity bioassay in rats and mice with vinyl fluoride. Fundam Appl Toxicol 26(2): 223-38. (mammary gland adenocarcinoma mentioned in abstract)
Bogdanffy MS, Makovec GT, Frame SR. Inhalation oncogenicity bioassay in rats and mice with vinyl fluoride. Fundam Appl Toxicol 1995;26(2):223-38.
Primary Literature
Elevated at all doses, but not dose response.
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review
Not nominated for NTP testing in 1998-2003.