Environment and Breast Cancer: Science Review


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ethyl methanesulfonate
CAS RN 62-50-0



Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
National Toxicology Program 11th Report on Carcinogens
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
NTP 11ROC: In a study not reviewed by IARC, when administered in the drinking water, ethyl methanesulfonate induced multiple moderately differentiated mammary adenocarcinomas in young rats of both sexes and mature female rats.
Only review sources are listed for this chemical because of lower likelihood of exposure.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 7 (1974) (p. 245) Ethyl Methanesulfonate. Summary of Data Reported and Evaluation.
Review
Does not mention mammary tumors.
National Toxicology Program 11th Report on Carcinogens. Ethyl Methanesulfonate
Review
In a study not reviewed by IARC, when administered in the drinking water, ethyl methanesulfonate induced multiple moderately differentiated mammary adenocarcinomas in young rats of both sexes and mature female rats (Ueo et al. 1981). -Ueo, H., R. Takaki, H. Yamagami and K. Sugimachi. 1981. Mammary carcinoma induced by oral administration of ethyl methanesulphonate. Determination of some of the parameters affecting tumor induction. Carcinogenesis 2(12): 1223-8.
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review
Not nominated for NTP testing in 1998-2003.