Environment and Breast Cancer: Science Review


Search the Mammary Carcinogens Reviews Database

nitrofurazone
CAS RN 59-87-0



Cancer studies: Mammary gland tumors
Print this page
Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
Carcinogenicity Potency Database, National Toxicology Program studies, IARC Monographs, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
IARC 1990: In rats, an increased incidence of mammary fibroadenomas was observed in females when administered orally in two studies.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 50 (1990) (p. 195) Nitrofural (Nitrofurazone). Summary of Data Reported and Evaluation.
Review
Administration by diet induced mammary tumors in female rats. [The Working Group noted that data on survival were not given]: Erturk 1970. Administration by diet induced mammary tumors in female rats: National Toxicology Program 1988, Kari 1989.
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
Three of three studies report mammary tumors: NTP TR337, Morris 1969 and Erturk 1970.
Erturk E, Morris JE, Cohen SM, Price JM, Bryan GT. Transplantable rat mammary tumors induced by 5-nitro-2-furaldehyde semicarbazone and by formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl] hydrazide. Cancer Res 1970;30(5):1409-12.
Primary Literature
Morris JE, Price JM, Lalich JJ, Stein RJ. The carcinogenic activity of some 5-nitrofuran derivatives in the rat. Cancer Res 1969;29(12):2145-56.
Primary Literature
Kari FW, Huff JE, Leininger J, Haseman JK, Eustis SL. Toxicity and carcinogenicity of nitrofurazone in F344/N rats and B6C3F1 mice. Food Chem Toxicol. 1989 Feb;27(2):129-37.
Primary Literature
From IARC
National Toxicology Program Technical Report 337, 1988
Primary Literature
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review
Not nominated for NTP testing in 1998-2003.