Environment and Breast Cancer: Science Review

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Key References
Abbreviations
 

glycidol
CAS RN 556-52-5

Chemical Summary
Exposure and Risk Assessment
Cancer Studies
 


Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
Carcinogenicity Potency Database, IARC Monographs, National Toxicology Program studies, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
One study reported mammary tumors. The study that did, an NTP Technical Report, reported high rates of mortality and mammary tumors in female and male rats and female mice.
Only review sources are listed for this chemical because of lower likelihood of exposure.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 77 (2000) (p. 469)
Review
By oral admin, mammary tumors in female mice and female rats: Irwin et.al 1996 and NTP 1990.
http://monographs.iarc.fr/ENG/Monographs/vol77/volume77.p...
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
One (NTP TR 374) of 2 studies reviewed reported mammary tumors. Lijinsky 1992 did not report mammary tumors.
http://potency.berkeley.edu/pdfs/ChemicalTable.pdfpotency...
National Toxicology Program 11th Report on Carcinogens.
Review
Lists mammary tumors in male and female rats and female B6C3F1 mice. Sources are NTP TR 374 and IARC 2000.
http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s092gl...
National Toxicology Program Technical Report 374, 1990
Primary Literature

experimental details
Increased animal death due to neoplasms, esp mammary neoplasms in female rats. Increased benign mammary tumors in male and female rats. Increase malignant mammary tumors in female rats and female mice. Rats: 0, 37.5, 75 mg/kg, 5 ml/kg Mice: 0, 25, 50 mg/kg; 10 ml/kg female rat: 14/49, 32/46, 29/44 T+ fibroadenoma male rat: 3/45, 8/39, 7/17* T+ fibroadenoma female rat: 1/50, 11/48*, 16/48* T+ adenocarcinoma 14/50, 34/50*, 37/50* T+ fibroadenoma or adenocarcinoma female mice: 1/50, 5/50, 15/50* T+ adenocarcinoma 2/50, 6/50, 15/50* mix T+ (ad, fibad, adc)
http://ntp.niehs.nih.gov/ntp/htdocs/LT_rpts/tr374.pdf
Lijinsky W, Kovatch RM. A study of the carcinogenicity of glycidol in Syrian hamsters. Toxicol Ind Health 1992;8(5):267-71.
Primary Literature
A study listed by CPDB 2005 that did not report mammary tumors. Study does not focus on a particular organ site and may have been able to pick up on generated mammary tumors
Irwin, Eustis, Stefanski, Haseman (1996) Carcinogenicity of glycidol in F344 rats and B6C3F1 mice. J. appl. Toxicol., 16, 201-209.
Primary Literature
From IARC, review postponed.