Environment and Breast Cancer: Science Review

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Key References
Abbreviations
 

n-hydroxy-2-(acetylamino)fluorene
CAS RN 53-95-2

Chemical Summary
Exposure and Risk Assessment
Cancer Studies
 


Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
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Only review sources are listed for this chemical because of lower likelihood of exposure.
Citation
Source Type
Notes
National Library of Medicine. (CCRIS) Chemical Carcinogenesis Research Information System. [cited 2005 September 30]
Review
19 total references. 7 references mention mammary tumors. 5 references are from Publication 149 (see end). -GUTMANN,HR, MALEJKA-GIGANTI,D, BARRY,EF AND RYDELL,RE; ON THE CORRELATION BETWEEN THE HEPATOCARCINOGENICITY OF THE CARCINOGEN, N-2-FLUORENYLACETAMIDE, AND ITS METABOLIC ACTIVATION BY THE RAT; CANCER RES. 32:1554-1556, 1972 -IMAIDA,K, HIROSE,M, TAY,L, LEE,MS, WANG,CY AND KING,CM; COMPARATIVE CARCINOGENICITIES OF 1-, 2-, AND 4-NITROPYRENE AND STRUCTURALLY RELATED COMPOUNDS IN THE FEMALE CD RAT; CANCER RES. 51:2902-2907, 1991 -National Institutes of Health; National Cancer Institute. Survey of Compounds which have been tested for Carcinogenic Activity: Formerly US Public Health Service Publication No. 149 [CD-ROM]. In: National Institutes of Health; National Cancer Institute; 2003.
http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?CCRIS
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review
Not nominated for NTP testing in 1998-2003.
http://ntp.niehs.nih.gov/ntp/roc/eleventh/tab1.pdf