Environment and Breast Cancer: Science Review

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Key References
Abbreviations
 

thiotepa
CAS RN 52-24-4

Chemical Summary
Exposure and Risk Assessment
Cancer Studies
 


Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
IARC Monographs, National Toxicology Program studies, National Toxicology Program 11th Report on Carcinogens, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
NTP 11ROC: In rats, intraperitoneal injection of thiotepa caused malignant mammary tumors in females. Malignant mammary gland tumors were significantly increased in the NTP study, however the study authors come to conflicting conclusions as to whether the increase is related to administration of thiotepa. This finding does not appear in the study abstract.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 50 (1990) (p. 123) Thiotepa. Summary of Data Reported and Evaluation.
Review
Intraperitoneal injections induced mammary tumors in female rats. [The Working Group noted the high mortality among high- and mid-dose groups, which necessitated the later inclusion of the lower dose-treated group, and that the study design included controls pooled from different studies]: National Cancer Institute 1978.
http://monographs.iarc.fr/ENG/Monographs/vol50/volume50.p...
National Toxicology Program 11th Report on Carcinogens. Thiotepa
Review
In rats, intraperitoneal injection caused malignant mammary tumors in females (NCI 1978, IARC 1975, 1990).
http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s174th...
National Toxicology Program Technical Report 58, 1978
Primary Literature
http://ntp.niehs.nih.gov/ntp/htdocs/LT_rpts/tr058.pdf
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review
Not nominated for NTP testing in 1998-2003.
http://ntp.niehs.nih.gov/ntp/roc/eleventh/tab1.pdf