Environment and Breast Cancer: Science Review
AboutCancer studies: Mammary gland tumors
Originating list
The list(s) or database(s) in which the chemical was identified as showing an
increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC:
International Agency for Research on Chemicals Monographs on the Evaluation of
Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program
(NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical
Carcinogenesis Research Information Service.
IARC Monographs, National Toxicology Program 11th Report on Carcinogens, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most
often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases,
supplemented by our evaluation of individual studies and reviews, is available for the priority
chemicals and 67 others.
NTP 11ROC: Intraperitoneal injections of 1,8-dinitropyrene induced mammary adenocarcinoma in female rats. The incidences of mammary tumors, including adenocarcinomas, were increased in female rats receiving 1,8-dinitropyrene by gavage.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 46 (1989) (p. 231) 1,8-Dinitropyrene.
Review
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
National Toxicology Program 11th Report on Carcinogens. Nitroarenes
Review
Imaida K, Lee MS, Land SJ, Wang CY, King CM. Carcinogenicity of nitropyrenes in the newborn female rat. Carcinogenesis 1995;16(12):3027-30.
Primary Literature
Imaida K, Lee MS, Wang CY, King CM. Carcinogenicity of dinitropyrenes in the weanling female CD rat. Carcinogenesis 1991;12(7):1187-91.
Primary Literature
King CM. Metabolism and biological effects of nitropyrene and related compounds. Res Rep Health Eff Inst 1988(16):1-22.
Primary Literature
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review