Environment and Breast Cancer: Science Review


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2,4-diaminoanisole sulfate
CAS RN 39156-41-7



Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
Carcinogenicity Potency Database, National Toxicology Program 11th Report on Carcinogens
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
NTP 11th ROC: When administered in the diet to female rats, 2,4-diaminoanisole sulfate induced mammary adenocarcinomas. An NTP study of 2,4-diaminoanisole sulfate did not find mammary gland tumors.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 79 (2001) (p. 621) 2,4-Diaminoanisole. Summary of Data Reported and Evaluation.
Review
Administration by diet induced mammary tumors. [The Working Group noted that no statistical analysis was provided]: Evarts 1980.
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
One of three studies reports mammary tumors: Evarts 1980. Two studies did not report mammary tumors: NTP TR84 and Hasegawa 1991.
National Toxicology Program 11th Report on Carcinogens. 2,4-Diaminoanisole Sulfate
Review
When administered in the diet to female rats, induced mammary adenocarcinomas (IARC 1982).
Evarts RP, Brown CA. 2,4-diaminoanisole sulfate: early effect on thyroid gland morphology and late effect on glandular tissue of Fischer 344 rats. J Natl Cancer Inst 1980;65(1):197-204.
Primary Literature
Hasegawa R, Shirai T, Hakoi K, Wada S, Yamaguchi K, Takayama S. Synergistic enhancement of thyroid tumor induction by 2,4-diaminoanisole sulfate, N,N'-diethylthiourea and 4,4'-thiodianiline in male F344 rats. Carcinogenesis 1991;12(8):1515-8.
Primary Literature
A study listed by CPDB 2005 that did not report mammary tumors.
Evarts RP, Brown CA. 2,4-diaminoanisole sulfate: early effect on thyroid gland morphology and late effect on glandular tissue of Fischer 344 rats. J Natl Cancer Inst. 1980 Jul;65(1):197-204.
Primary Literature
From IARC
National Toxicology Program Technical Report 84, 1978
Primary Literature
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review
Not nominated for NTP testing in 1998-2003.