Environment and Breast Cancer: Science Review
Cancer studies: Mammary gland tumors
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.IARC Monographs, National Toxicology Program 11th Report on Carcinogens, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.NTP 11th ROC: A single intravenous injection of Adriamycin® induced mammary tumors in female rats.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 10 (1976) (p. 43) Adriamycin. Summary of Data Reported and Evaluation.
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: Supplement 7 (1987) (p. 81) Adriamycin. Summary of Data Reported and Evaluation.
National Toxicology Program 11th Report on Carcinogens. Adriamycin.
Bertazzoli C, Chieli T, Solcia E. Different incidence of breast carcinomas or fibroadenomas in daunomycin or adriamycin treated rats. Experientia. 1971 Oct 15;27(10):1209-10.
Bucclarelli E. Mammary tumor induction in male and female Sprague-Dawley rats by adriamycin and daunomycin. J Natl Cancer Inst. 1981 Jan;66(1):81-4.
Casazza AM, Bellini O, Formelli F, Giuliani F, Lenaz L, Magrini U. Tumors and dental and ocular abnormalities after treatment of infant rats with adriamycin. Tumori. 1977 Jul-Aug;63(4):331-8.
Maltoni C, Chieco P. Adriamycin: a new potent carcinogen (Ital.). Osp Vita. 1975;2:107-9.
Marquardt H, Philips FS, Sternberg SS. Tumorigenicity in vivo and induction of malignant transformation and mutagenesis in cell cultures by adriamycin and daunomycin. Cancer Res. 1976 Jun;36(6):2065-9.
Solcia E, Ballerini L, Bellini O, Sala L, Bertazzoli C. Mammary tumors induced in rats by adriamycin and daunomycin. Cancer Res. 1978 May;38(5):1444-6.
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.