Environment and Breast Cancer: Science Review

Overview    |    Publications    |    Epidemiology Reviews Database    |    Mammary Carcinogens Review Database

Search the Mammary Carcinogens Reviews Database
About
Browse
Search
Key References
Abbreviations
 

chlordane
CAS RN 12789-03-6

Chemical Summary
Exposure and Risk Assessment
Cancer Studies
 


Cancer studies: Mammary gland tumors
Print this page
Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
Very limited evidence of mammary gland tumors.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 79 (2001) (p. 411) Chlordane and Heptachlor. Summary of Data Reported and Evaluation.
Review
Does not mention mammary tumors.
http://monographs.iarc.fr/ENG/Monographs/vol79/volume79.p...
National Library of Medicine. (CCRIS) Chemical Carcinogenesis Research Information System. [cited 2005 September 30]
Review
3 references total. 1 reference mention mammary tumors. -KHASAWINAH,AM AND GRUTSCH,JF; CHLORDANE: THIRTY-MONTH TUMORIGENICITY AND CHRONIC TOXICITY TEST IN RATS; REGUL. TOXICOL. PHARMACOL. 10(2):95-109, 1989
http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?CCRIS
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review
Nominated by: NIEHS in 1988 and Citizens Against Pesticide Misuse in 1989. Rationale: - Previous carcinogenicity studies considered to be inadequate - Extensive human exposure - Chlordane has a long half-life and is frequently identified in hazardous waste sites and in ground water. - Although chemical is no longer used, there is significant human exposure from contaminated homes. - Toxic effects observed in people exposed to chlordane Current NTP Status: Analytical (Reagent) Grade: http://ntp-server.niehs.nih.gov/htdocs/Results_Status/Resstatc/57749.Html Technical Grade: http://ntp-server.niehs.nih.gov/htdocs/Results_Status/Resstatc/10849-T.Html
http://ntp.niehs.nih.gov/ntp/roc/eleventh/tab1.pdf