Environment and Breast Cancer: Science Review
Cancer studies: Mammary gland tumors
Originating list
The list(s) or database(s) in which the chemical was identified as showing an
increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC:
International Agency for Research on Chemicals Monographs on the Evaluation of
Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program
(NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical
Carcinogenesis Research Information Service.
Carcinogenicity Potency Database, IARC Monographs, National Toxicology Program studies, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most
often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases,
supplemented by our evaluation of individual studies and reviews, is available for the priority
chemicals and 67 others.
Two of four studies noted mammary tumors. One of the "negative" studies was only looking for liver tumors. All studies used feed as exposure route while predominantly dermal or inhalation exposures are expected for the general population.
Only review sources are listed for this chemical because of lower likelihood of exposure.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man. VOL.: 65 (1996) (p. 309) 2,4-Dintrotoluene, 2,6-dinitrotoluene and 3,5-dinitrotoluene.
Review
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
Lee CC, Hong CB, Ellis HV, III, Dacre JC, Glennon JP. Subchronic and chronic toxicity studies of 2,4-dinitrotoluene. Part II. CD rats. J. Am. Coll. Toxicol. 1985;4:243-256.
National Toxicology Program Technical Report 54, 1978
Hong CB, Ellis HV, III, Lee CC, Sprinz H, Dacre JC, Glennon JP. Subchronic and chronic toxicity studies of 2,4-dinitrotoluene. Part III. CD-1 mice. J. Am. Coll. Toxicol. 1985;4:257-269
Primary Literature
Leonard TB, Graichen ME, Popp JA. Dinitrotoluene isomer-specific hepatocarcinogenesis in F344 rats. J Natl Cancer Inst 1987;79(6):1313-9.
Primary Literature
National Toxicology Program 11th Report on Carcinogens,
Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review