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2,4-dinitrotoluene
CAS RN 121-14-2



Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
Carcinogenicity Potency Database, IARC Monographs, National Toxicology Program studies, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
Two of four studies noted mammary tumors. One of the "negative" studies was only looking for liver tumors. All studies used feed as exposure route while predominantly dermal or inhalation exposures are expected for the general population.
Only review sources are listed for this chemical because of lower likelihood of exposure.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man. VOL.: 65 (1996) (p. 309) 2,4-Dintrotoluene, 2,6-dinitrotoluene and 3,5-dinitrotoluene.
Review
Noted mammary tumors from two oral administration studies in rats. Oral rat NTP TR 1978 and Lee 1985.
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
2 of 4 studies cited show mammary tumors: NTP TR54 and Lee 1985. Studies that did not report mammary tumors were Leonard 1987 and Hong 1985.
Lee CC, Hong CB, Ellis HV, III, Dacre JC, Glennon JP. Subchronic and chronic toxicity studies of 2,4-dinitrotoluene. Part II. CD rats. J. Am. Coll. Toxicol. 1985;4:243-256.
Primary Literature

experimental details
Increased benign mammary tumors in male and unspecified mammary tumors in female rats. 0, 0.0015%, 0.01%, 0.07% in daily feed for 2 yrs. male: 0/25, 0/27, 0/19, 2/27 T+adenoma or fibroadenoma, female: 11/23, 1/28, 16/26, 21/25 T+ benign and malignant,significance not calculated for any of above
National Toxicology Program Technical Report 54, 1978
Primary Literature

experimental details
Increased benign mammary tumors in female rats. Actual dose unknown. Rats: 0 (2 control groups), 0.0075% of feed for 19 wks then 0.008% for 59 wks, 0.02% of feed for 78 wks. female rats: 13/71, 12/49, 23/50* T+ fibroadenoma
Hong CB, Ellis HV, III, Lee CC, Sprinz H, Dacre JC, Glennon JP. Subchronic and chronic toxicity studies of 2,4-dinitrotoluene. Part III. CD-1 mice. J. Am. Coll. Toxicol. 1985;4:257-269
Primary Literature
A study listed by CPDB 2005 that did not report mammary tumors. No obvious reason for mammary tumors to have been overlooked. Study is similar to and performed by same authors as Lee et al 1985.
Leonard TB, Graichen ME, Popp JA. Dinitrotoluene isomer-specific hepatocarcinogenesis in F344 rats. J Natl Cancer Inst 1987;79(6):1313-9.
Primary Literature
A study listed by CPDB 2005 that did not report mammary tumors. Authors were only evaluating liver tumors.
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review
Not nominated for NTP testing in 1998-2003.