Environment and Breast Cancer: Science Review


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acrylonitrile
CAS RN 107-13-1



Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
IARC Monographs, Carcinogenicity Potency Database, National Toxicology Program 11th Report on Carcinogens, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
NTP 11th ROC: When administered orally, acrylonitrile induced increased incidence of mammary gland carcinomas in rats of both sexes. Inhalation studies demonstrated that acrylonitrile induced mammary tumors in female rats. An NTP study of acrylonitrile in mice did not find mammary gland tumors.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 71 (1999) (p. 43) Acrylonitrile.
Review
One study in rats by inhalation with pre- and post-natal exposure found increases in malignant mammary tumors: Maltoni (rat inhalation and described two unpublished studies of rat inhalation and drinking water within it) 1987 [The Working Group noted that full reports of these studies have not been published in the peer reviewed scientific literature.]
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
Three of four studies report mammary tumors: 2 Quast studies in 1980, Maltoni 1988. One study did not report mammary tumors: Gallagher 1988.
National Toxicology Program 11th Report on Carcinogens. Acrylonitrile
Review
When administered orally (by gavage or in drinking water), acrylonitrile induced increased incidences of mammary gland carcinomas. Inhalation studies demonstrated acrylonitrile induced mammary tumors in female rats (IARC 1999).
Gallagher GT, Maull, E. A., Kovacs, K., and Szabo, S. Neoplasms in rats ingesting acrylonitrile for two years. J. Am. Coll. Toxicol. 1988;7:603-615.
Primary Literature
A study listed by CPDB 2005 that did not report mammary tumors.
Maltoni C, Ciliberti A, Cotti G, Perino G. Long-term carcinogenicity bioassays on acrylonitrile administered by inhalation and by ingestion to Sprague-Dawley rats. Ann N Y Acad Sci 1988;534:179-202.
Primary Literature
National Toxicology Program Technical Report 506, 2001
Primary Literature
No mammary gland tumors found in mice; rats not evaluated in this study.
Quast JF, Schuetz, D. J., Balmer, M. F., Gushow, T. S., Park, C. N., and McKenna, M. J. A Two-year Toxicity and Oncogenicity Study with Acrylonitrile Following Inhalation Exposure of Rats. Final Report. Midland, MI: Dow Chemical U.S.A.; 1980
Primary Literature
Quast JF, Wade, C. E., Humiston, C. G., Carreon, R. M., Hermann, E. A., Park, C. N., and Schwetz, B. A. A Two-year Toxicity and Oncogenicity Study with Acrylonitrile Incorporated in the Drinking Water of Rats. Midland, MI: Dow Chemical U.S.A.; 1980
Primary Literature
Maltoni C, Cilberti a cotti g, perino g. Experimental Research on acrylonitrile carcinogenesis (Maltoni c and mehlman ma eds, Archives of research on industrial carcinogenesis, vol VI) Princeton, NJ Princeton Sci Publishing.
Primary Literature
From IARC, review postponed.