Environment and Breast Cancer: Science Review
Cancer studies: Mammary gland tumors
Originating list
The list(s) or database(s) in which the chemical was identified as showing an
increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC:
International Agency for Research on Chemicals Monographs on the Evaluation of
Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program
(NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical
Carcinogenesis Research Information Service.
Carcinogenicity Potency Database, IARC Monographs, National Toxicology Program studies, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most
often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases,
supplemented by our evaluation of individual studies and reviews, is available for the priority
chemicals and 67 others.
NTP 11th ROC: When administered by inhalation, 1,2-dibromoethane induced increased incidence of fibroadenomas of the mammary gland in female rats. 1,2-dibromoethane administered by inhalation induced adenocarcinomas of the mammary gland in female mice.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 71 (1999) (p. 641) Ethylene Dibromide.
Review
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
National Toxicology Program 11th Report on Carcinogens. 1,2-Dibromoethane
Review
Van Duuren BL, Melchionne S, Seidman I, Pereira MA. Chronic bioassays of chlorinated humic acids in B6C3F1 mice. Environ Health Perspect 1986;69:109-17.
Primary Literature
Van Duuren BL, Seidman I, Melchionne S, Kline SA. Carcinogenicity bioassays of bromoacetaldehyde and bromoethanol--potential metabolites of dibromoethane. Teratog Carcinog Mutagen 1985;5(6):393-403.
Primary Literature
National Toxicology Program Technical Report 210, 1982
National Toxicology Program Technical Report 86, 1978.
Primary Literature
Wong LC, Winston JM, Hong CB, Plotnick H. Carcinogenicity and toxicity of 1,2-dibromoethane in the rat. Toxicol Appl Pharmacol 1982;63(2):155-65.
Primary Literature