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1,2-dibromoethane
CAS RN 106-93-4



Cancer studies: Mammary gland tumors
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Originating list
The list(s) or database(s) in which the chemical was identified as showing an increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC: International Agency for Research on Chemicals Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program (NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical Carcinogenesis Research Information Service.
Carcinogenicity Potency Database, IARC Monographs, National Toxicology Program studies, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases, supplemented by our evaluation of individual studies and reviews, is available for the priority chemicals and 67 others.
NTP 11th ROC: When administered by inhalation, 1,2-dibromoethane induced increased incidence of fibroadenomas of the mammary gland in female rats. 1,2-dibromoethane administered by inhalation induced adenocarcinomas of the mammary gland in female mice.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 71 (1999) (p. 641) Ethylene Dibromide.
Review
When administered by inhalation, produced mammary gland tumors in mice and rats: NTP TR210, 1982.
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
Three of five studies reported mammary tumors: NTP TR210, NTP TR86, and Wong 1982. Two studies did not report mammary tumors: Van Duuren 1985 and 1986.
National Toxicology Program 11th Report on Carcinogens. 1,2-Dibromoethane
Review
When administered by inhalation, induced increased incidences of fibroadenomas of the mammary gland in female rats and adenocarinomas of the mammary gland in female mice (NCI 1978, NTP 1982).
Van Duuren BL, Melchionne S, Seidman I, Pereira MA. Chronic bioassays of chlorinated humic acids in B6C3F1 mice. Environ Health Perspect 1986;69:109-17.
Primary Literature
A study listed by CPDB 2005 that did not report mammary tumors.
Van Duuren BL, Seidman I, Melchionne S, Kline SA. Carcinogenicity bioassays of bromoacetaldehyde and bromoethanol--potential metabolites of dibromoethane. Teratog Carcinog Mutagen 1985;5(6):393-403.
Primary Literature
A study listed by CPDB 2005 that did not report mammary tumors.
National Toxicology Program Technical Report 210, 1982
Primary Literature

experimental details
Increases in malignant mammary tumors in female mice and benign tumors in female rats. 0, 10, 40 ppm for 6 hrs/d, 5d/wk for 78 weeks-103 weeks Female mice: 2/50, 14/50*, 8/50* adenocarcinoma T+ Female rats: 4/50, 29/50*, 24/50* fibroadenoma T+ Female rats: 1/50, 0/50, 4/50 adenocarcinoma T+ Has a second NTP Technical Report: TR86, 1978 which used gavage instead of inhalation.
National Toxicology Program Technical Report 86, 1978.
Primary Literature
Wong LC, Winston JM, Hong CB, Plotnick H. Carcinogenicity and toxicity of 1,2-dibromoethane in the rat. Toxicol Appl Pharmacol 1982;63(2):155-65.
Primary Literature