Environment and Breast Cancer: Science Review
AboutCancer studies: Mammary gland tumors
Originating list
The list(s) or database(s) in which the chemical was identified as showing an
increase in mammary gland tumors. CPDB: Carcinogenic Potency Database, IARC:
International Agency for Research on Chemicals Monographs on the Evaluation of
Carcinogenic Risk of Chemicals to Man summaries, NTP TR: National Toxicology Program
(NTP) Technical Reports, NTP 11ROC: NTP 11th Report on Carcinogens, CCRIS: Chemical
Carcinogenesis Research Information Service.
Carcinogenicity Potency Database, IARC Monographs, National Toxicology Program 11th Report on Carcinogens, Chemical Carcinogenesis Research Information System
Mammary gland tumor summary
A summary of findings related to mammary gland tumors, most
often excerpted from IARC Monographs or the NTP 11th ROC, and, in some cases,
supplemented by our evaluation of individual studies and reviews, is available for the priority
chemicals and 67 others.
NTP 11th ROC: When administered in the diet, 4,4-methylene-bis(2-chloroaniline) induced mammary adenocarcinomas in male rats.
Citations to review sources and individual studies reporting mammary gland tumors are listed below.
Citation
Source Type
Notes
International Agency for Research on Cancer, Monographs on the evaluation of carcinogenic risk of chemicals to man.VOL.: 57 (1993) (p. 271) 4,4 '-methylene-bis(2-chloroaniline) (MOCA). Summary of Data Reported and Evaluation.
Review
Carcinogenic Potency Database 2005. Gold LS ST, Manley NB, Garfinkel GB, Ames BN. Summary Table by Chemical of Carcinogenicity Results in CPDB on 1485 Chemicals. 2005
Review
National Toxicology Program 11th Report on Carcinogens. 4,4 '-methylene-bis(2-chloroaniline)
Review
Grundmann E, Steinhoff D. Liver and lung tumors following 3,3'-dichloro-4,4'-diamino-diphenylmethane in rats (German). Z Krebsforsch. 1970;74(1):28-39.
Primary Literature
Kommineni C, Groth DH, Frockt IJ, Voelker RW, Stanovick RP. Determination of the tumorigenic potential of methylene-bis-orthochloroaniline. J Environ Pathol Toxicol. 1979 May-Jun;2(5):149-71.
Primary Literature
Stula EF, Sherman H, Zapp JA, Jr., Clayton JW, Jr. Experimental neoplasia in rats from oral administration of 3,3'-dichlorobenzidine, 4,4'-methylene-bis-bis(2-chloroaniline), and 4,4'-methylene-bis(2-methylaniline). Toxicol Appl Pharmacol. 1975 Jan;31(1):159-76.
Primary Literature
Stula EF, Barnes JR, Sherman H, Reinhardt CF, Zapp JA, Jr. Urinary bladder tumors in dogs from 4,4'-methylene-bis (2-chloroaniline) (MOCA). J Environ Pathol Toxicol. 1978 Sep-Oct;1(1):31-50.
Primary Literature
National Toxicology Program 11th Report on Carcinogens, Table 1. Chemicals nominated to the National Toxicology Program for in-depth toxicological evaluation for carcinogenesis testing in fiscal years 1988-2003.
Review